2025

Kuroda Y, Iida J, Murata K, Hori Y, Kobiki J, Minatoya K, Masumoto H*. Transplantation of vascularized cardiac microtissue from human iPS cells improves impaired electrical conduction in a porcine myocardial injury model. JTCVS Open. In press. doi: doi.org/10.1016/j.xjon.2025.03.006.

Iida J, Kotani K, Murata K, Hakamada K, Maihemuti W, Mandai Y, Hiraoka Y, Minatoya K, Masumoto H*. Retention of locally injected human iPS cell-derived cardiomyocytes into the myocardium using hydrolyzed gelatin. Sci Rep. 2025;15:4635. doi: 10.1038/s41598-025-87885-w.

2024

Maihemuti W, Murata K, Abulaiti M, Minatoya K, Masumoto H*. Simultaneous electro-dynamic stimulation accelerates maturation of engineered cardiac tissues generated by human iPS cells. Biochem Biophys Res Commun. 2024;733:150605. doi: 10.1016/j.bbrc.2024.150605.

Yang Q, Murata K, Ikeda T, Minatoya K, Masumoto H*. miR-124-3p downregulates EGR1 to suppress ischemia-hypoxia reperfusion injury in human iPS cell-derived cardiomyocytes. Sci Rep. 2024;14:14811. doi: 10.1038/s41598-024-65373-x.

Heima D, Takeda M, Tabata Y, Minatoya K, Yamashita JK*, Masumoto H*. Therapeutic potential of human induced pluripotent stem cell-derived cardiac tissue in an ischemic model with unloaded condition mimicking left ventricular assist device. J Thorac Cardiovasc Surg. 2024;168:e72-e88. doi: 10.1016/j.jtcvs.2023.11.019.

2023

Murata K, Makino A, Tomonaga K*, Masumoto H*. Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model. iScience. 2023;27:108641. doi: 10.1016/j.isci.2023.108641. (※Cover image)

Kanemitsu E, Zhao X, Iwaisako K, Inoue A, Takeuchi A, Yagi S, Masumoto H, Ohara H, Hosokawa M, Awaya T, Aoki J, Hatano E, Uemoto S, Hagiwara M*. Antagonist of sphingosine 1-phosphate receptor 3 reduces cold injury of rat donor hearts for transplantation. Transl Res. 2023;255:26-36. doi: 10.1016/j.trsl.2022.11.003.

2022

Kyo S, Murata K, Kawatou M, Minatoya K, Sunagawa GA*, Masumoto H*. Quiescence-inducing neurons-induced hypometabolism ameliorates acute kidney injury in a mouse model mimicking cardiovascular surgery requiring circulatory arrest. JTCVS Open. 2022 Nov 8;12:201-210. doi: 10.1016/j.xjon.2022.11.001.

Ho WJ, Kobayashi M, Murata K, Hashimoto Y, Izumi K, Kimura T, Kanemitsu H, Yamazaki K, Ikeda T, Minatoya K, Kishida A, Masumoto H*. A novel approach for the endothelialization of xenogeneic decellularized vascular tissues by human cells utilizing surface modification and dynamic culture. Sci Rep. 2022 Dec 24;12(1):22294. doi: 10.1038/s41598-022-26792-w.

Konegawa Y, Kuwahara T, Jo JI, Murata K, Takeda T, Ikeda T, Minatoya K, Masumoto H*, Tabata Y*. Pioglitazone-incorporated microspheres targeting macrophage polarization alleviates cardiac dysfunction after myocardial infarction. Eur J Cardiothorac Surg. 2022;62:ezac414. doi: 10.1093/ejcts/ezac414.

Murata K, Masumoto H*. Systems for the Functional Evaluation of Human Heart Tissues Derived from Pluripotent Stem Cells. Stem Cells. 2022;40:537-545. doi: 10.1093/stmcls/sxac022. Review.

Fujiwara Y, Hirao S, Yamazaki K, Ikeda T, Minatoya K, Masumoto H*. Evaluations for surrounding tissue incorporation after implantation of synthetic vascular prostheses in animal models. J Artif Organs. 2022;25:24-33. doi: 10.1007/s10047-021-01283-3.

2021

Osada H, Kawatou M, Fujita D, Tabata Y, Minatoya K, Yamashita JK*, Masumoto H*. Therapeutic potential of clinical-grade human induced pluripotent stem cell-derived cardiac tissues. JTCVS Open. 2021;8:359-374. doi: 10.1016/j.xjon.2021.09.038.

Masumoto H*. Generation of Cylindrical Engineered Cardiac Tissues from Human iPS Cell-Derived Cardiovascular Cell Lineages. Methods Mol Biol. 2021;2320:81-88. doi: 10.1007/978-1-0716-1484-6_9.

Kurokawa S, Hashimoto Y, Funamoto S, Murata K, Yamashita A, Yamazaki K, Ikeda T, Minatoya K, Kishida A, Masumoto H*. In vivo recellularization of xenogeneic vascular grafts decellularized with high hydrostatic pressure method in a porcine carotid arterial interpose model. PLoS One. 2021 Jul 22;16(7):e0254160. doi: 10.1371/journal.pone.0254160.

Dwenger M, Kowalski WJ, Masumoto H, Nakane T, Keller BB*. Chronic Optogenetic Pacing of Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues. Methods Mol Biol. 2021;2191:151-169. doi: 10.1007/978-1-0716-0830-2_10.

2020

Osada H, Ho WJ, Yamashita H, Yamazaki K, Ikeda T, Minatoya K, Masumoto H*. Novel device prototyping for endoscopic cell sheet transplantation using a three-dimensional printed simulator. Regen Ther. 2020;15:258-264. doi: 10.1016/j.reth.2020.10.007.

Abulaiti M, Yalikun Y, Murata K, Sato A, Sami MM, Sasaki Y, Fujiwara Y, Minatoya K, Shiba Y, Tanaka Y, Masumoto H*. Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function. Sci Rep. 2020;10:19201. doi: 10.1038/s41598-020-76062-w.

Murata K, Ikegawa M, Minatoya K, Masumoto H*. Strategies for immune regulation in iPS cell-based cardiac regenerative medicine. Inflamm Regen. 2020 Sep 29;40:36. doi: 10.1186/s41232-020-00145-4. Review.

Osada H, Kawatou M, Takeda M, Jo JI, Murakami T, Tabata Y, Minatoya K, Yamashita JK, Masumoto H*. Accuracy of spiked cell counting methods for designing a pre-clinical tumorigenicity study model. Heliyon. 2020;6:e04423. doi: 10.1016/j.heliyon.2020.e04423.

Nakane T, Abulaiti M, Sasaki Y, Kowalski WJ, Keller BB, Masumoto H*. Preparation of Mesh-Shaped Engineered Cardiac Tissues Derived from Human iPS Cells for In Vivo Myocardial Repair. J Vis Exp. 2020;(160). doi: 10.3791/61246.

Nishio H, Minatoya K, Masumoto H*. A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure. J Vis Exp. 2020;(159). doi: 10.3791/60931.

Takai F, Takeda T, Yamazaki K, Ikeda T, Hyon SH, Minatoya K, Masumoto H*. Management of retrosternal adhesion after median sternotomy by controlling degradation speed of a dextran and ε-poly (L-lysine)-based biocompatible glue. Gen Thorac Cardiovasc Surg. 2020;68:793-800. doi: 10.1007/s11748-020-01297-3.

Itonaga T, Hirao S, Yamazaki K, Ikeda T, Minatoya K, Masumoto H*. The N-terminal lectin-like domain of thrombomodulin reduces acute lung injury without anticoagulant effects in a rat cardiopulmonary bypass model. Gen Thorac Cardiovasc Surg. 2020;68:785-792. doi: 10.1007/s11748-020-01292-8.

Nagasawa A, Masumoto H, Yanagi S, Kanemitsu N, Ikeda T, Tabata Y, Minatoya K*. Basic fibroblast growth factor attenuates left-ventricular remodeling following surgical ventricular restoration in a rat ischemic cardiomyopathy model. Gen Thorac Cardiovasc Surg. 2020;68:311-318. doi: 10.1007/s11748-019-01187-3.

2019

Dwenger M, Kowalski WJ, Ye F, Yuan F, Tinney JP, Setozaki S, Nakane T, Masumoto H, Campbell P, Guido W, Keller BB*. Chronic optical pacing conditioning of h-iPSC engineered cardiac tissues. J Tissue Eng. 2019;10:2041731419841748. doi: 10.1177/2041731419841748.

Nishio H, Masumoto H*, Sakamoto K, Yamazaki K, Ikeda T, Minatoya K. MicroRNA-145-loaded poly(lactic-co-glycolic acid) nanoparticles attenuate venous intimal hyperplasia in a rabbit model. J Thorac Cardiovasc Surg. 2019;157:2242-2251. doi: 10.1016/j.jtcvs.2018.08.115.

2018

Masumoto H*, Yamashita JK*. Human iPS cell-engineered three-dimensional cardiac tissues perfused by capillary networks between host and graft. Inflamm Regen. 2018;38:26. doi: 10.1186/s41232-018-0084-7. Review.

Ishigami M, Masumoto H*, Ikuno T, Aoki T, Kawatou M, Minakata K, Ikeda T, Sakata R, Yamashita JK*, Minatoya K. Human iPS cell-derived cardiac tissue sheets for functional restoration of infarcted porcine hearts. PLoS One. 2018;13(8):e0201650. doi: 10.1371/journal.pone.0201650.

Li Z, Masumoto H*, Jo JI, Yamazaki K, Ikeda T, Tabata Y, Minatoya K. Sustained release of basic fibroblast growth factor using gelatin hydrogel improved left ventricular function through the alteration of collagen subtype in a rat chronic myocardial infarction model. Gen Thorac Cardiovasc Surg. 2018;66:641-647. doi: 10.1007/s11748-018-0969-z.

Kumagai M, Minakata K, Masumoto H*, Yamamoto M, Yonezawa A, Ikeda T, Uehara K, Yamazaki K, Ikeda T, Matsubara K, Yokode M, Shimizu A, Tabata Y, Sakata R, Minatoya K. A therapeutic angiogenesis of sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel sheets in a canine chronic myocardial infarction model. Heart Vessels. 2018;33:1251-1257. doi: 10.1007/s00380-018-1185-6.

Hirao S, Masumoto H*, Itonaga T, Minatoya K. A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats. J Vis Exp. 2018;(133):56986. doi: 10.3791/56986.

Takeda M, Kanki Y, Masumoto H, Funakoshi S, Hatani T, Fukushima H, Izumi-Taguchi A, Matsui Y, Shimamura T, Yoshida Y, Yamashita JK*. Identification of Cardiomyocyte-Fated Progenitors from Human-Induced Pluripotent Stem Cells Marked with CD82. Cell Rep. 2018;22:546-556. doi: 10.1016/j.celrep.2017.12.057.

Tsumaru S, Masumoto H*, Minakata K, Izuhara M, Yamazaki K, Ikeda T, Ono K, Sakata R, Minatoya K. Therapeutic angiogenesis by local sustained release of microRNA-126 using poly lactic-co-glycolic acid nanoparticles in murine hindlimb ischemia. J Vasc Surg. 2018;68:1209-1215. doi: 10.1016/j.jvs.2017.08.097.

2017

Kawatou M, Masumoto H, Fukushima H, Morinaga G, Sakata R, Ashihara T, Yamashita JK*. Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue. Nat Commun. 2017;8:1078. doi: 10.1038/s41467-017-01125-y.

Hirao S, Minakata K, Masumoto H*, Yamazaki K, Ikeda T, Minatoya K, Sakata R. Recombinant human soluble thrombomodulin prevents acute lung injury in a rat cardiopulmonary bypass model. J Thorac Cardiovasc Surg. 2017;154:1973-1983.e1. doi: 10.1016/j.jtcvs.2017.05.051.

Kowalski WJ, Yuan F, Nakane T, Masumoto H, Dwenger M, Ye F, Tinney JP, Keller BB*. Quantification of Cardiomyocyte Alignment from Three-Dimensional (3D) Confocal Microscopy of Engineered Tissue. Microsc Microanal. 2017;23:826-842. doi: 10.1017/S1431927617000666.

Nakane T, Masumoto H, Tinney JP, Yuan F, Kowalski WJ, Ye F, LeBlanc AJ, Sakata R, Yamashita JK, Keller BB*. Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue. Sci Rep. 2017;7:45641. doi: 10.1038/srep45641.

Ikuno T, Masumoto H, Yamamizu K, Yoshioka M, Minakata K, Ikeda T, Sakata R, Yamashita JK*. Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP. PLoS One. 2017;12:e0173271. doi: 10.1371/journal.pone.0173271.

Masumoto H*, Yamashita JK*. Untiring steps toward the maturation of human stem cell-engineered heart tissue. Ann Transl Med. 2017;5:87. doi: 10.21037/atm.2017.01.60. Comment.

Taki T, Masumoto H*, Funamoto M, Minakata K, Yamazaki K, Ikeda T, Sakata R. Fetal mesenchymal stem cells ameliorate acute lung injury in a rat cardiopulmonary bypass model. J Thorac Cardiovasc Surg. 2017;153:726-734. doi: 10.1016/j.jtcvs.2016.10.014.

Setozaki S, Minakata K*, Masumoto H, Hirao S, Yamazaki K, Kuwahara K, Ikeda T, Sakata R. Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model. J Vasc Surg. 2017;65:1803-1812.e2. doi: 10.1016/j.jvs.2016.06.003.

2016

Masumoto H*, Yamashita JK*. Human iPS Cell-Derived Cardiac Tissue Sheets: a Platform for Cardiac Regeneration. Curr Treat Options Cardiovasc Med. 2016;18:65. doi: 10.1007/s11936-016-0489-z. Review.

Masumoto H†, Nakane T†, Tinney JP, Yuan F, Ye F, Kowalski WJ, Minakata K, Sakata R, Yamashita JK, Keller BB*. The myocardial regenerative potential of three-dimensional engineered cardiac tissues composed of multiple human iPS cell-derived cardiovascular cell lineages. (†equal contribution） Sci Rep. 2016;6:29933. doi: 10.1038/srep29933.

Funamoto M, Masumoto H, Takaori K, Taki T, Setozaki S, Yamazaki K, Minakata K, Ikeda T*, Hyon SH, Sakata R. Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass. Ann Thorac Surg. 2016 Apr;101(4):1507-13. doi: 10.1016/j.athoracsur.2015.09.080.

2015

Matsuo T, Masumoto H, Tajima S, Ikuno T, Katayama S, Minakata K, Ikeda T, Yamamizu K, Tabata Y, Sakata R, Yamashita JK*. Efficient long-term survival of cell grafts after myocardial infarction with thick viable cardiac tissue entirely from pluripotent stem cells. Sci Rep. 2015;5:16842. doi: 10.1038/srep16842.

2014

Masumoto H, Ikuno T, Takeda M, Fukushima H, Marui A, Katayama S, Shimizu T, Ikeda T, Okano T, Sakata R, Yamashita JK*. Human iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration. Sci Rep. 2014;4:6716. doi: 10.1038/srep06716.

Ohnaka M, Marui A, Yamahara K, Minakata K, Yamazaki K, Kumagai M, Masumoto H, Tanaka S, Ikeda T, Sakata R*. Effect of microRNA-145 to prevent vein graft disease in rabbits by regulation of smooth muscle cell phenotype. J Thorac Cardiovasc Surg. 2014;148:676-82.e2. doi: 10.1016/j.jtcvs.2013.11.054.

Nakano J, Marui A, Muranaka H, Masumoto H, Noma H, Tabata Y, Ido A, Tsubouchi H, Ikeda T, Sakata R*. Effects of hepatocyte growth factor in myocarditis rats induced by immunization with porcine cardiac myosin. Interact Cardiovasc Thorac Surg. 2014;18:300-7. doi: 10.1093/icvts/ivt512.

2013

Kamitani T†, Masumoto H†, Kotani H, Ikeda T, Hyon SH, Sakata R*. Prevention of retrosternal adhesion by novel biocompatible glue derived from food additives. (†equal contribution） J Thorac Cardiovasc Surg. 2013;146:1232-8. doi: 10.1016/j.jtcvs.2013.02.001.

2012

Masumoto H, Sakata R*. Cardiovascular surgery for realization of regenerative medicine. Gen Thorac Cardiovasc Surg. 2012;60:744-55. doi: 10.1007/s11748-012-0139-7. Review.

Masumoto H, Matsuo T, Yamamizu K, Uosaki H, Narazaki G, Katayama S, Marui A, Shimizu T, Ikeda T, Okano T, Sakata R, Yamashita JK*. Pluripotent stem cell-engineered cell sheets reassembled with defined cardiovascular populations ameliorate reduction in infarct heart function through cardiomyocyte-mediated neovascularization. Stem Cells. 2012;30:1196-205. doi: 10.1002/stem.1089.

2009

Masumoto H*, Shimamoto M, Yamazaki F, Nakai M, Fujita S, Miura Y, Itonaga T, Ito H. A case report of valve dysfunction associated with abrasion of the Delrin disk used in early Björk-Shiley mitral valves requiring resurgery. Ann Thorac Cardiovasc Surg. 2009;15(2):126-8. Case report.

2008

Masumoto H*, Shimamoto M, Yamazaki F, Nakai M, Fujita S, Miura Y. Airway stenosis associated with a mycotic pseudoaneurysm of the common carotid artery. Gen Thorac Cardiovasc Surg. 2008;56:242-5. doi: 10.1007/s11748-008-0230-2. Case report.

2007

Masumoto H*, Shimamoto M, Yamazaki F, Nakai M, Fujita S, Itonaga T, Nomura R. A case of heparin-induced thrombocytopenia with repeated episodes of acute lower extremity arterial thromboembolism during a short time. Ann Thorac Cardiovasc Surg. 2007;13:365-7. Case report.