京都大学医学部附属病院心臓血管外科 次世代循環器医療開発プロジェクト

主要論文

Murata K, Takamura K, Watanabe R, Nagashima A, Miyauchi M, Miyauchi Y, Masumoto H*. Production of bioactive cytokines using plant expression system for cardiovascular cell differentiation from human pluripotent stem cells. Stem Cell Res Ther. 2025;16:303. doi: doi.org/10.1186/s13287-025-04424-0.

Kuroda Y, Iida J, Murata K, Hori Y, Kobiki J, Minatoya K, Masumoto H*. Transplantation of vascularized cardiac microtissue from human iPS cells improves impaired electrical conduction in a porcine myocardial injury model. JTCVS Open. 2025;25:154-62. doi: doi.org/10.1016/j.xjon.2025.03.006.

Murata K, Makino A, Tomonaga K*, Masumoto H*. Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model. iScience. 2023;27:108641. doi: 10.1016/j.isci.2023.108641. (※Cover image)

Kyo S, Murata K, Kawatou M, Minatoya K, Sunagawa GA*, Masumoto H*. Quiescence-inducing neurons-induced hypometabolism ameliorates acute kidney injury in a mouse model mimicking cardiovascular surgery requiring circulatory arrest. JTCVS Open. 2022 Nov 8;12:201-210. doi: 10.1016/j.xjon.2022.11.001.

Abulaiti M, Yalikun Y, Murata K, Sato A, Sami MM, Sasaki Y, Fujiwara Y, Minatoya K, Shiba Y, Tanaka Y, Masumoto H*. Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function. Sci Rep. 2020;10:19201. doi: 10.1038/s41598-020-76062-w.

Kawatou M, Masumoto H, Fukushima H, Morinaga G, Sakata R, Ashihara T, Yamashita JK*. Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue. Nat Commun. 2017;8:1078. doi: 10.1038/s41467-017-01125-y.

Setozaki S, Minakata K*, Masumoto H, Hirao S, Yamazaki K, Kuwahara K, Ikeda T, Sakata R. Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model. J Vasc Surg. 2017;65:1803-1812.e2. doi: 10.1016/j.jvs.2016.06.003.

Masumoto H, Ikuno T, Takeda M, Fukushima H, Marui A, Katayama S, Shimizu T, Ikeda T, Okano T, Sakata R, Yamashita JK*. Human iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration. Sci Rep. 2014;4:6716. doi: 10.1038/srep06716.

Masumoto H, Matsuo T, Yamamizu K, Uosaki H, Narazaki G, Katayama S, Marui A, Shimizu T, Ikeda T, Okano T, Sakata R, Yamashita JK*. Pluripotent stem cell-engineered cell sheets reassembled with defined cardiovascular populations ameliorate reduction in infarct heart function through cardiomyocyte-mediated neovascularization. Stem Cells. 2012;30:1196-205. doi: 10.1002/stem.1089.