Message from the Principal Investigator

Message from the Principal Investigator

This page introduces the vision, research philosophy, and challenges of our laboratory as we integrate regenerative medicine, cardiac organoids, drug discovery, and translational research toward next-generation cardiovascular medicine.

Hidetoshi Masumoto
Project-Specific Professor
Hidetoshi Masumoto MD, PhD
masumoto [at] kuhp.kyoto-u.ac.jp

MD, PhD; board-certified specialist in regenerative medicine and cardiology/cardiovascular care. He graduated from Kyoto University Faculty of Medicine in 1999. After positions in cardiovascular surgery at Kumamoto Chuo Hospital and Shizuoka City Shizuoka Hospital, a postdoctoral fellowship at the University of Louisville, and an appointment as Program-Specific Assistant Professor at the Center for iPS Cell Research and Application (CiRA), Kyoto University, he became Project-Specific Associate Professor in the Department of Cardiovascular Surgery, Kyoto University Hospital in 2023, and assumed his current position in April 2025.

From October 2017 to March 2025, he led the laboratory as Research Team Leader of the Clinical Translation Program at the RIKEN Center for Biosystems Dynamics Research (and since April 2025, as Visiting Chief Scientist at RIKEN). In 2023, he became the first Japan-based principal investigator selected for the Novartis Institutes for BioMedical Research Global Scholars Program.

His research centers on the structural and functional maturation of cardiac organoids generated from iPS cells, with the goal of developing new regenerative therapies for severe heart disease and drug discovery platforms based on human cardiac disease modeling.

Message

“Toward the Future of Regenerative Medicine: Innovating Next-Generation Cardiovascular Therapy”

Cardiovascular disease is becoming an increasingly serious challenge in aging societies. Yet treatment options for patients with severe cardiac disorders remain limited, and the development of new therapeutic strategies is an urgent priority. Our laboratory is committed to creating new treatments for heart disease through regenerative medicine, centered on the construction and functional maturation of cardiac organoids derived from iPS cells. Through this work, we hope to provide therapeutic options that are not dependent solely on transplantation, while also accelerating drug discovery through human cardiac disease modeling.

In this project, we place strong emphasis on bridging basic research and clinical application. By collaborating with specialists in medicine, engineering, pharmaceuticals, and biotechnology, we are working to establish the foundations of next-generation cardiovascular medicine. In particular, we promote the development of novel treatment strategies based on cell technologies and biomaterials, together with the systems needed to deliver these innovations to real clinical settings.

This challenge cannot be achieved without the collaboration of many researchers, clinicians, and industry partners. We believe that truly innovative therapies emerge when experts from different fields join forces and build on each other’s strengths. We hope to continue this challenge together with all who share the goal of creating next-generation cardiovascular medicine and delivering new hope to more patients.
Affiliations

Professional Societies & Public Activities

The Japanese Association for Thoracic Surgery (Regular Member)
The Japanese Society for Cardiovascular Surgery (International Member)
Japan Surgical Society
Japanese Circulation Society
Japanese Heart Failure Society
Japanese Society for Regenerative Medicine (Council Member)
Japanese Society of Inflammation and Regeneration
Japan Society of Drug Delivery System
Japanese Society of Cardio-Oncology
American Heart Association (Professional Member)
European Society of Cardiology (Professional Member)
International Society for Stem Cell Research
The Asian Society for Cardiovascular and Thoracic Surgery
Steering Committee Member, DDS Regenerative Medicine Research Group
Executive Committee Member, Japanese Society for Cardiovascular Surgery Regenerative Medicine Study Group
AMED-RS Project: “Establishment of Quality Evaluation Methods for Organoid-based Human Cell Products”
Member, Guideline Development Working Group for Therapeutic Organoid Quality Evaluation (FY2025–)
Awards

Selected Awards

2019 — Best Presentation Award, 49th Annual Meeting of the Japanese Society for Cardiovascular Surgery
2013 — Excellent Presentation Award, 9th Miyazaki Science Camp
2012 — Best Poster Award, 33rd Annual Meeting of the Japanese Society of Inflammation and Regeneration
2012 — Young Investigator Award (YIA), Best Award in Basic Research, 4th Meeting of the Japanese Society for Regenerative Medicine
2011 — Excellent Presentation Award, 32nd Annual Meeting of the Japanese Society of Inflammation and Regeneration
Media

Selected Press Coverage

Major media reports and press releases featuring the laboratory’s work and activities.

[RIKEN / Kyoto University Press Release] “Bioactive proteins produced in plants accelerate cardiac regenerative medicine: development of a safe cytokine production platform using plant expression systems”, June 25, 2025. Covered by Sankei Shimbun, Mainichi Shimbun, Nikkei, Tokyo Shimbun, Kobe Shimbun, Kyodo News, and others.
[RIKEN / Kyoto University Press Release] “A heart failure pandemic to watch for in the post-COVID era: persistent SARS-CoV-2 infection may increase heart failure risk”, December 23, 2023. Covered by Mainichi Shimbun, Kobe Shimbun, Kyodo News, Sankei News, and others.
[Kyoto University Press Release] “Hidetoshi Masumoto selected for a global research support program for the first time from Japan”, February 20, 2023. Announcement of selection to the Novartis Global Scholars Program.
[RIKEN / Kyoto University Press Release] “The potential of induced hibernation for safer cardiovascular surgery: protecting organs from ischemia through a hibernation-like state”, November 14, 2022. Covered by NHK Kansai, ABEMA Hills, Asahi Shimbun, Yomiuri Shimbun, Nikkei, and others.
[Kyoto University Press Release] “Development of an endoscopic device for transplanting cell sheets onto the heart surface with reduced surgical burden: toward application in cardiac regenerative medicine”, November 20, 2020. Covered by Kyoto Shimbun, Sankei Shimbun, Nikkan Kogyo Shimbun, Nikkei, Yomiuri TV News, TV Osaka News, and others.
[RIKEN Press Release] “Understanding human heart function using iPS cells: development of a heart-on-a-chip microdevice”, November 5, 2020. Featured in Nikkan Kogyo Shimbun and on the RIKEN YouTube channel.